| 肿瘤血管生成与大肠癌肝转移 |
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| 引用本文： | Xie Z,Huang X,Li J,Zhou L. 肿瘤血管生成与大肠癌肝转移[J]. 中华外科杂志, 1999, 37(6): 336-337,I021 |
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| 作者姓名： | Xie Z Huang X Li J Zhou L |
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| 作者单位： | 北京医科大学北京市肿瘤研究所外科 |
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| 摘 要： | 目的分析大肠癌肿瘤血管生成与转移、预后的关系。方法用免疫组化法检测６１例大肠癌手术标本肿瘤组织微血管密度（ＭＶＤ）、血管内皮生长因子（ＶＥＧＦ）的表达。结果ＭＶＤ计数为（２７０±８４）、ＶＥＧＦ表达为（５９７５±１２３６）％,二者与肝、淋巴结转移明显相关（Ｐ＜００１、Ｐ＜００５）。ＭＶＤ计数与术后生存率明显相关（Ｐ＜００１）。结论ＭＶＤ计数与大肠癌肝转移、生存率明显相关,可作为一个新的具有参考意义的预后判断指标。
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| 关 键 词： | 大肠肿瘤 肝转移 血管生成因子 |
Liver metastasis in colorectal cancer and tumor angiogenesis |
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| Xie Z,Huang X,Li J,Zhou L. Liver metastasis in colorectal cancer and tumor angiogenesis[J]. Chinese Journal of Surgery, 1999, 37(6): 336-337,I021 |
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| Authors: | Xie Z Huang X Li J Zhou L |
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| Affiliation: | Department of Surgery, Institute of Cancer Research, Beijing Medical University, Beijing 100036. |
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| Abstract: | Objective To investigate the association between tumor angiogenetic activity and metastatic potential of colorectal cancer (CRC) retrospectively. Methods The microvessel density(MVD) and the level of vascular endothelial growth factor(VEGF) expression were examined imunohistochemically from 61 specimens obtained by surgical resection of CRC. Results MVD was (27084) and the expression of VEGF was (59751236)%. Both were significantly higher in the group of liver metastasis,and in the group of lymph node metastasis(P<001,P<005).Survival analysis indicated a significant difference between increasing MVD group and the control group(P<001). ConclusionsBZVEGFmediated angiogenesis plays an important role in liver metastasis of CRC, and MVD appears to be a new prognostic factor for the prediction of outcome in patients with CRC. |
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| Keywords: | Colorectal neoplasmsNeoplasms metastasisLiverAngiogenesis factor |
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