| 大肠癌患者门静脉血癌细胞的检测及临床意义 |
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| 作者姓名： | Luo C Li S |
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| 作者单位： | 北京军区总医院普外科 |
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| 摘 要： | 目的 探讨门静脉血管癌细胞与大肠癌肝转移的关系。方法 以非核素ＲＴ－ＰＣＲ方法,对５４例大肠癌患者门静脉血中结肠癌细胞的标志物细胞角质蛋白２０（ＣＫ２０）进行了检测。结果 ５４例中,４１例门静脉血中检出ＣＫ２０阳性表达,阳性率７５．９％,ＣＫ２０阳性检出与Ｄｕｋｅｓ分期,肝转移存在显著性相关,随着Ｄｕｋｅｓ分期的进展ＣＫ２０阳性率显著增加,随访发现,门静脉血ＣＫ２０扩增阳性者,术后发生肝转移机会增
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| 关 键 词： | 大肠肿瘤 肝转移 门静脉血 癌细胞 检测 |
The detection and its clinical significance of cancer cells in portal vein blood of patients with colorectal carcinoma |
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| Luo C,Li S.The detection and its clinical significance of cancer cells in portal vein blood of patients with colorectal carcinoma[J].Chinese Journal of Surgery,1999,37(4):214-215. |
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| Authors: | Luo C Li S |
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| Institution: | Department of General Surgery, Beijing General Hospital of People's Leberation Army, Beijing 100700. |
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| Abstract: | Objective To study the relation between cancer cells in portal vein blood and liver metastasis of colorectal carcinoma. Methods The presence of CK20 mRNA was investigated by non isotope RT PCR in 54 cases. Results The positive rate of CK2O mRNA in portal vein blood was 75 9%. The positive cases were significantly correlated with Dukes stage and live metastasis. There was a higher probability of liver metastasis in positive cases after operation. Conclusions The detection of CK20 in portal vein blood may improve the accuracy of clinical staging and diagnose liver micrometastasis of colorectal carcinoma. |
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