肉毒碱治疗TPN大鼠肝脂肪变性的研究

目的 探讨在全胃肠外营养（ＴＰＮ）中补充肉毒碱减轻肝脂肪变性的作用。方法 １８只正常Ｗｉｓｔａｒ大鼠和１９只肝硬化Ｗｉｓｔａｒ大鼠分别随机分为６组,Ａ１组、Ａ２组,自由进食和进水（各６只）;Ｂ１组、Ｂ２组,ＴＰＮ（分别６只、７只）;Ｃ１组、 ,ＴＰＮ加肉毒碱（各６只）。各组实验结束后测肝功能,肝脂肪及行肝脏的组织学检查。结果 ＴＰＮ组肝内脂肪显著２,ＴＰＮ＋肉毒碱组肝内脂肪明显减少。结论 在ＴＰＮ

Study on therapeutic effect of carnitine on hepatic steatosis caused by total parenteral nutrition in rats

Objective To study the hepatic steatosis minimizing effects of carnitine supplemented total parenteral nutrition(TPN). Methods Eighteen normal Wistar rats and nineteen cirrhotic Wistar rats were randomly divided into three groups, respectively: group A(12), chow and libitum; group B(13), TPN for one week group C(12), TPN with carnitine. Liver functions were tested at the seventh day, and also, the liver was resected for histological studies and lipid content determination. Results Hepatic lipid content was significantly elevated and hepatic steatosis was noted in group B. Hepatic lipid content and hepatic lipid deposit were significantly lowered when carnitine was added to the TPN solution. Conclusions Carnitine can minimize hepatic steatosis caused by TPN.