| 当归补血微丸的制备及其质量控制 |
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| 引用本文： | 陈红霞,贾晓斌,陈彦,孙晶,潘国梁,成旭东. 当归补血微丸的制备及其质量控制[J]. 中国药房, 2006, 17(19): 1476-1477 |
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| 作者姓名： | 陈红霞 贾晓斌 陈彦 孙晶 潘国梁 成旭东 |
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| 作者单位： | 1. 江苏大学药学院,镇江市,212001
2. 江苏省中医药研究院,南京市,210028 |
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| 基金项目： | 江苏省卫生厅"135工程"医学重点人才基金 |
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| 摘 要： | 目的制备当归补血微丸并建立其质量控制方法。方法以挤出滚圆法制备当归补血微丸,考察微丸的粉体学性质和溶散时限,并采用高效液相色谱法测定微丸中阿魏酸的含量。结果所制微丸圆整度、流动性好,溶散时限合格。阿魏酸进样量在0.03438μg~1.146μg范围内线性关系良好(r=0.9998),平均回收率为97.0%(RSD=0.664%)。结论该制剂制备方法可行;所建立的含量测定方法准确、灵敏、稳定性好,可用于该制剂的质量控制。
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| 关 键 词： | 挤出滚圆法 当归补血微丸 阿魏酸 高效液相色谱法 |
| 文章编号： | 1001-0408(2006)19-1476-02 |
| 收稿时间： | 2006-03-14 |
| 修稿时间： | 2006-05-08 |
Preparation and Quality Control of Danggui Buxue Pellets |
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| CHEN Hongxia,JIA Xiaobin,CHEN Yan,SUN Jing,PAN Guoliang,CHENG Xudong. Preparation and Quality Control of Danggui Buxue Pellets[J]. China Pharmacy, 2006, 17(19): 1476-1477 |
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| Authors: | CHEN Hongxia JIA Xiaobin CHEN Yan SUN Jing PAN Guoliang CHENG Xudong |
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| Affiliation: | 1School of Pharmacy, Jiangsu University, Zhenjiang 212001, China ;2Jiangsu Provincial Academy of TCM, Nanjing 210028, China |
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| Abstract: | OBJECTIVE:To prepare traditional Chinese medicine formula danggui buxue pellets by extrusion-spheroniza_tion and to establish its quality control method.METHODS:Danggui buxue pellets were prepared by extrusion - spheronization pelletizer.The micromeritic properties of pellets and its dissolution time limit were determined,the content of ferulic acid in pellets was detected by HPLC.RESULTS:Danggui buxue pellets by extrusion-spheronization were all spheral with smooth surface,good in flowability and qualified in dissolution time limit. The linearity of ferulic acid was in the range of 0.03 438 μg ～1.146μg(r=0.9 998),and the average recovery was 97.0%(RSD=0.664%).CONCLUSION:The method is feasible;The determination is accurate,sensitive,stable,and suitable for the quality control of danggui buxue pellets. |
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| Keywords: | Extrusion-spheronization Danggui buxue pellets Ferulic acid HPLC |
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