| 慢病毒载体的改进及其在血液病基因治疗中的应用 |
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| 引用本文： | 主鸿鹄,徐开林. 慢病毒载体的改进及其在血液病基因治疗中的应用[J]. 中国实验血液学杂志, 2003, 11(2): 208-212 |
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| 作者姓名： | 主鸿鹄 徐开林 |
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| 作者单位： | 江苏省徐州医学院附属医院血液科,徐州,221002 |
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| 摘 要： | 慢病毒载体（lentiviral vector，LV)具有可感染非分裂细胞、转移基因片段容量较大、目的基因表达时间长、不易诱发宿主免疫反应等优点，成为目前较有前途的病毒载体。本以人类免疫缺陷病毒I型(HIV—I)为代表，综述对LV的改进及其在血液病基因治疗转移基因中的应用。
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| 关 键 词： | 慢病毒载体 血液病 基因治疗 宿主免疫反应 人类免疫缺陷病毒I型 |
| 文章编号： | 1009-2137(2003)02-0208-05 |
| 修稿时间： | 2002-04-29 |
Improvements of Lentiviral Vector and Its Application in Gene Therapy of Hematological Diseases |
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| ZHU Hong Hu,XU Kai Lin. Improvements of Lentiviral Vector and Its Application in Gene Therapy of Hematological Diseases[J]. Journal of experimental hematology, 2003, 11(2): 208-212 |
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| Authors: | ZHU Hong Hu XU Kai Lin |
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| Affiliation: | Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China. |
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| Abstract: | As lentiviral vector holds the characteristics of higher transfection to non-dividing cells, larger capacity of transfer gene fragments, long-term expression of therapeutic gene and lower rate of immunological response, therefore it becomes potential viral vector in gene therapy. Improvements of lentiviral vector, human immunodeficiency virus type-I as example, and its application in gene transfer for gene therapy of hematological diseases are emphasized in this review. |
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