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Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma |
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| Authors: | Tsz-Kwong?Man,Xin-Yan?Lu,Kim?Jaeweon,Laszlo?Perlaky,Charles?P?Harris,Shishir?Shah,Marc?Ladanyi,Richard?Gorlick,Ching?C?Lau,Pulivarthi?H?Rao author-information" > author-information__contact u-icon-before" > mailto:phrao@txccc.org" title=" phrao@txccc.org" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA;(2) Spectral Genomics, Houston, TX, USA;(3) Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA;(4) Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA |
| Abstract: | BackgroundOsteosarcoma is a highly malignant bone neoplasm of children and young adults. It is characterized by extremely complex karyotypes and high frequency of chromosomal amplifications. Currently, only the histological response (degree of necrosis) to therapy represent gold standard for predicting the outcome in a patient with non-metastatic osteosarcoma at the time of definitive surgery. Patients with lower degree of necrosis have a higher risk of relapse and poor outcome even after chemotherapy and complete resection of the primary tumor. Therefore, a better understanding of the underlying molecular genetic events leading to tumor initiation and progression could result in the identification of potential diagnostic and therapeutic targets. |
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