| Notch信号在肢体远程预处理诱导脑保护机制研究 |
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| 引用本文： | 吕文英,熊利泽,董海龙,张丽娜,张昊鹏,王世全,王丛丛,郭超.Notch信号在肢体远程预处理诱导脑保护机制研究[J].中华神经外科疾病研究杂志,2011,10(3):214-217. |
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| 作者姓名： | 吕文英 熊利泽 董海龙 张丽娜 张昊鹏 王世全 王丛丛 郭超 |
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| 作者单位： | 第四军医大学西京医院麻醉科,陕西西安,710032 |
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| 基金项目： | 国家自然科学基金资助项目(30930091) |
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| 摘 要： | 目的探讨Notch信号通过在肢体远程预处理脑缺血中的神经保护作用。方法将大脑中动脉阻闭120分钟(MCAO)制备大鼠局灶性脑缺血模型,将36只雄性SD大鼠随机分为假手术组(Sham)、MCAO组和肢体远端缺血预处理(RIPC)组+MCAO组(n=12),分别观察各组大鼠脑梗死灶的大小和神经功能学评分,并用免疫组织化学染色检测再灌注2 h、24 h、72 h大鼠脑组织纹状体区Notch信号通路胞内活化片段NICD(Notch intracellular domain)表达的变化。结果 RIPC组脑梗死容积小于MCAO组,差异有统计学意义(P<0.05),其神经功能学评分也明显优于MCAO组(P<0.05)。各时相点RIPC组Notch表达明显少于MCAO组(P<0.05)。结论肢体远程预处理所诱导的脑缺血耐受的机制可能与Notch信号表达的降低有关。
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| 关 键 词： | 远程缺血预处理 Notch信号 大脑中动脉阻闭 脑保护 |
Notch signaling in neuroprotection induced by remote ischcmic preconditioning in cerebral ischemia-reperfusion |
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| LV Wenying,XIONG Lize,DONG Hailong,ZHANG Lina,ZHANG Haopeng,WANG Shiquan,WANG Congcong,GUO Chao.Notch signaling in neuroprotection induced by remote ischcmic preconditioning in cerebral ischemia-reperfusion[J].Chinese Journal of Neurosurgical Disease Research,2011,10(3):214-217. |
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| Authors: | LV Wenying XIONG Lize DONG Hailong ZHANG Lina ZHANG Haopeng WANG Shiquan WANG Congcong GUO Chao |
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| Institution: | LV Wenying,XIONG Lize,DONG Hailong,ZHANG Lina,ZHANG Haopeng,WANG Shiquan,WANG Congcong,GUO Chao Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China |
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| Abstract: | Objective To investigate the role of Notch signaling in the neuroprotection after remote ischemic preconditioning (RIPC) in rat model of local cerebral ischemia. Methods Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (MCAO) for 120 min to establish a local cerebral ischemic model. A total of 36 male rats were randomly assigned to three groups (n = 12): sham group, MCAO group, and RIPC + MCAO group. Infarction volume of the brain tissue and neurologic scores were evaluated. ... |
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| Keywords: | Remote ischemic preconditioning Notch signal MCAO Neuroprotection |
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