Genetic Regulation of Pre-Pubertal Development of Body Mass Index: A Longitudinal Study of Japanese Twin Boys and Girls |
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| Authors: | Karri Silventoinen Jaakko Kaprio Yoshie Yokoyama |
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| Institution: | (1) Population Research Unit, Department of Social Research, University of Helsinki, Helsinki, Finland;(2) Department of Public Health, University of Helsinki, P.O. Box 41, Mannerheimintie 172, 00014 Helsinki, Finland;(3) Department of Mental Health, National Institute for Health and Welfare, Helsinki, Finland;(4) Institute for Molecular Medicine FIMM, Helsinki, Finland;(5) Department of Community Health Nursing, Osaka City University, Osaka, Japan |
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| Abstract: | We analyzed the genetic architecture of prepubertal development of relative weight to height in 216 monozygotic and 159 dizygotic
complete Japanese twin pairs (52% girls). Ponderal index at birth (kg/m3) and body mass index (BMI, kg/m2) from 1 to 11 years of age were used. Additive genetic factors explained the major proportion (52–74%) of the variation of
BMI from 1 to 11 years of age. Environmental factors common to both co-twins also showed some effect (7–28%), but at most
ages this was not statistically significant. Strong genetic tracking was found for BMI from 1 to 11 years of age, but there
was also evidence for a persistent effect of common environmental factors. Our results suggest that the genetic architecture
of BMI development in the Japanese population is generally similar to that found in previous twin studies in Caucasian populations. |
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