牙周基础治疗对老年牙周疾病患者血清炎性标记物的影响

目的 观察患有牙周病的老年人经过牙周基础治疗后,其冠心病相关血清炎性标记物的变化.方法 选择老年牙周病患者52例,记录其探诊深度(probing depth,PD)、附着水平(attachment level AL)、C-反应蛋白(C-reactive protein,CRP)和白细胞介素-6(interleukin-6 IL-6)水平.牙周基础治疗后3个月、6个月再次检查牙周临床指标,测定CRP和IL-6水平,比较治疗前后各项指标的变化.结果 治疗后6个月,PD和AL值分别为(5.9±1.1)mm和(6.8±1.0)mm,与治疗前分别为(7.5±1.2)mm和(8.4±1.1)mm]比较,差异有统计学意义(均P＜0.05).CRP和IL-6分别为(1.5±0.2)mg/L和(1.6±0.5)ng/L,与治疗前分别为(2.0±0.3)mg/L和(1.9±0.4)mg/L]比较,差异有统计学意义(分别为P＜0.01,P＜0.05).结论 牙周基础治疗能降低老年牙周疾病患者冠心病相关血清炎性标记物CRP和IL-6的水平.

Abstract：

Objective To ascertain serum inflammatory markers could be modified following treatment of periodontal disease in elderly patients. Methods The probing depth (PD), clinical attachment level (AL), C-reactive protein (CRP), interleukin-6 (IL-6) were determined. And then fifty-two elderly periodontitis patients underwent a standard phase of non-surgical periodontitis treatment (consisting of oral hygiene instructions and subgingival scaling and root planning). After three and six months, PD, AL, CRP and IL-6 were determined again and compared to the baseline. Results Six months after treatment, significant reductions in PD (5.9±1.1) mm vs. (6.8±1.0) mm, P＜0.05], AL (1.3±0.9) mm vs.(8.4±1.1) mm, P＜0.05], CRP (1.5±0.2) mg/L vs. (2.0±0.3) mg/L, P＜0.01] and IL-6 (1.6±0.5) ng/L vs. (1.9±0.4) ng/L, P＜0.05] were observed. Conclusions Treatment of chronic periodontitis can decrease the levels of serum inflammatory markers in elderly patients.

Effect of treatment of chronic periodontitis on level of serum inflammatory markers in elderly patients

Objective To ascertain serum inflammatory markers could be modified following treatment of periodontal disease in elderly patients. Methods The probing depth (PD), clinical attachment level (AL), C-reactive protein (CRP), interleukin-6 (IL-6) were determined. And then fifty-two elderly periodontitis patients underwent a standard phase of non-surgical periodontitis treatment (consisting of oral hygiene instructions and subgingival scaling and root planning). After three and six months, PD, AL, CRP and IL-6 were determined again and compared to the baseline. Results Six months after treatment, significant reductions in PD (5.9±1.1) mm vs. (6.8±1.0) mm, P＜0.05], AL (1.3±0.9) mm vs.(8.4±1.1) mm, P＜0.05], CRP (1.5±0.2) mg/L vs. (2.0±0.3) mg/L, P＜0.01] and IL-6 (1.6±0.5) ng/L vs. (1.9±0.4) ng/L, P＜0.05] were observed. Conclusions Treatment of chronic periodontitis can decrease the levels of serum inflammatory markers in elderly patients.