瑞格列奈与格列吡嗪治疗初发2型糖尿病疗效观察

目的比较瑞格列奈和格列吡嗪治疗初发2型糖尿病的疗效差异。方法将80例初发2型糖尿病患者随机分成瑞格列奈组和格列吡嗪组。瑞格列奈组采用瑞格列奈治疗。格列吡嗪组采用格列吡嗪治疗，监测2组治疗前及治疗后的空腹及餐后2h血糖。治疗前及治疗后12周及24周糖化血红蛋白，治疗前及治疗后24周空腹C肽以及总胆固醇、体重和甘油三脂的变化，并观察有否低血糖等不良反应。结果瑞格列奈组和格列吡嗪组对空腹血糖、餐后2h血糖较治疗前有相似的下降效果（P〈0．05），糖化血红蛋白治疗后12周较治疗前明显下降（P〈0．05），24周时瑞格列奈组糖化血红蛋白优于格列吡嗪组。C-肽治疗后24周较治疗前明显增加，两组参数间比较无明显差异（P〉0．05）。结论瑞格列奈和格列吡嗪对初发2型糖尿病患者的降糖治疗均有效，但瑞格列奈控制糖化血红蛋白的能力。保护胰岛B细胞的功能方面优于格列吡嗪，且更安全。

Curative Effect of Repaglinide and Glipizide on Early Stage Type 2 Diabetes

Objective To compare the clinical effect of Repaglinide and Glipizide on the early stage of type 2 diabetes. Methods 80 cases of type 2 diabetes were randomly divided into 2 groups,and treated with Repaglinide and Glipizide for 24 weeks,and kept close watch on FBG,2hPG,HbA_1c,C-peptide,TC,Weight,TG,the reactions of low level blood sugar etc.. Results The lowering blood sugar effect of the two drugs was similar(P<0.05).The lowering level of both drugs of HbA_1c was very significant(P<0.05).Repaglinide was better than Glipizide after 24 weeks.Both drugs could increase the serum level of C-peptide in empty condition(P<0.05),but no significant difference existed(t>0.05). Conclusion Both Repaglinide and Glipizide are effective in lowering blood suger of early stage of type 2 diabetes,but Repaglinide has the advantages of controlling HbA_1c and proctecting the B-cell.Repaglinide is a good blood sugar lowering drug.