| 环孢霉毒A逆转急性髓系白血病多药耐药一例 |
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| 引用本文： | 赵春亭,卞寿庚,杨纯正,薛艳萍,刘瑞林,何一心,奕凤君,刘炳仁.环孢霉毒A逆转急性髓系白血病多药耐药一例[J].中华血液学杂志,1995(7). |
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| 作者姓名： | 赵春亭 卞寿庚 杨纯正 薛艳萍 刘瑞林 何一心 奕凤君 刘炳仁 |
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| 作者单位： | 中国医学科学院血液学研究所血液病医院 |
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| 基金项目： | 国家八五攻关项目基金、卫生部科学基金 |
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| 摘 要： | 报道一例急性髓系白血病（Ｍ＿（４ｂ）患者，经ＨＡＤ方案全量化疗两疗程无效，实验室检查示ｍｄｒｌｍＲＮＡ（＋），ｐ１７０阳性率３１％，多药耐药细胞群占４１．７６％，证实为多药耐药。第３疗程用环孢霉素Ａ（ＣｓＡ，４ｍｇ／ｋｇ，每日两次，第１～３天；２．５ｍｇ／ｋｇ，每日两次，第４～５天）加类似剂量的ＨＡＤ方案化疗，取得完全缓解，同时ｍｄｒｌｍＲＮＡ和ｐ１７０转阴，耐药细胞群消失。
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| 关 键 词： | 多药耐药，环孢霉素A，白血病，髓细胞性，急性 |
REVERSAL OF MULTIDRUG RESISTANCE BYCYCLOSPORINE A IN A PATIENT WITH ACUTEMYELOID LEUKEMIA |
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| Zhao Chunting, Bzan Shougeng, Yang Chunzheng, etal..REVERSAL OF MULTIDRUG RESISTANCE BYCYCLOSPORINE A IN A PATIENT WITH ACUTEMYELOID LEUKEMIA[J].Chinese Journal of Hematology,1995(7). |
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| Authors: | Zhao Chunting Bzan Shougeng Yang Chunzheng etal |
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| Abstract: | patient with acute myeloid leukemia M_(4b) showedno response to two courses of HAD regimenchemotherapy . Laboratory studies showed that mdr 1mRNA was positive , and p-170 positive cells and mul-tidrug resistance (MDR) cells were 31% and 41. 76%respectively in bone marrow . The patient was con-firmed to be MDR. Cyclosporine A (4mg/kg twice dai-ly for 3 days , then 2. smg/kg twice daily for 2 days) inaddition to the same HAD regimen was given in thethird course in order to reverse the MDR . The patientobtained CR after this course of therapy with both mdr1 mRNA and p-170 turning to negative and the disap-pearance of MDR cells. |
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| Keywords: | S Multidrug resistance CyclosporineA Acute mveloid leukemia |
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