Reaction of different functional zones in mouse thymus and spleen lymphoid tissue to γ-irradiation |
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| Authors: | M P Sapin L M Erofeeva D E Grigorenko B S Fedorenko |
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| Institution: | (1) Laboratory of Functional Anatomy, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | It is shown that immune organs respond to single γ-radiation of 6.9 Gy in a cyclic manner. Acute reaction characterized by
spontaneous lymphocyte lysis in the thymus and spleen develops on day 1 postirradiation and takes 3 and 7 days, respectively.
This is followed by enhancement of thymocyte mitotic activity and migration of young cells to the thymic cortex and splenic
lymphoid tissue. Twenty-one day postirradiation lymphoid cell populations in the thymus and spleen recover to 70–90 and 55–70%,
respectively.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 4, pp. 381–384, April, 1998 |
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| Keywords: | thymus spleen lymphocyte γ -irradiation |
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