| 依托泊苷白蛋白微球的制备 |
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| 引用本文： | 张志清,杨秀岭,孙莉,李素民,董佳丽,樊德厚,蒋俊康,王川平,王淑梅. 依托泊苷白蛋白微球的制备[J]. 中国药学杂志, 2000, 35(3): 171-173 |
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| 作者姓名： | 张志清 杨秀岭 孙莉 李素民 董佳丽 樊德厚 蒋俊康 王川平 王淑梅 |
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| 作者单位： | 1. 河北医科大学第二医院药剂科,石家庄,050000
2. 河北医科大学药学院94级实习生 |
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| 摘 要： | 目的：制备依托泊苷白蛋白微球，并对其形态学性质、载药量、体外释药特性进行研究。方法：用乳化热固化法制备依托泊苷白蛋白微球。结果：微球平均粒径(13.61士4.80)μm，含药量为(18.25士0.18)%，药物包封率为(45.45士1.27)96，体外释药符合Higuchi方程：Q=0.01591+0.09837t1/2(r=0.9975)。结论：用乳化热固化法制备的依托泊苷白蛋白微球外观圆整，载药量较高，体外释药符合长效制剂特征。
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| 关 键 词： | 依托泊苷 白蛋白 |
| 收稿时间： | 1999-09-09; |
Preparation of etoposide-loaded albumin microspheres |
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| Zhang Zhiqing. Preparation of etoposide-loaded albumin microspheres[J]. Chinese Pharmaceutical Journal, 2000, 35(3): 171-173 |
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| Authors: | Zhang Zhiqing |
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| Affiliation: | (Zhang ZQ),Yang Xiuling (Yang XL),Sun Li (Sun L |
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| Abstract: | OBJECTIVE:To prepare the etoposide bovine serum albumin microspheres (VP-BSA-MS) and to study the properties of its morphology,drug loading and release in vitro.METHODS:The VP BSA MS was prepared by emulsion heat stabilization techniques. RESULTS:The mean diameter of VP-BSA-MS was (13.61±4.80)μm.The drug loading was (18.25±0.18)% and the embedding ratio was (45.45±1.27)%.The in vitro release properties of VP BSA MS could be expressed by the Higuchis equation: Q=0.01591+0.09837t1/2(r=0.9975). CONCLUSION:The VP-BSA-MS prepared by emulsion heat stabilization techniques was regular in its morphology with a high drug loading and in vitro release properties conformed to long acting preparations. |
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| Keywords: | etoposide albumin microspheres |
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