Place-related neural responses in the monkey hippocampal formation in a virtual space |
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Authors: | Hori Etsuro Nishio Yoichi Kazui Kenichi Umeno Katsumi Tabuchi Eiichi Sasaki Kazuo Endo Shunro Ono Taketoshi Nishijo Hisao |
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Institution: | System Emotional Science, Graduate School of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan. |
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Abstract: | Place cells in the rodent hippocampal formation (HF) are suggested to be the neural substrate for a spatial cognitive map. This specific spatial property of the place cells are regulated by both allothetic cues (i.e., intramaze local and distal cues) as well as idiothetic sensory inputs; the context signaled by the distal cues allows local and idiothetic cues to be employed for spatial tuning within the maze. To investigate the effects of distal cues on place-related activity of primate HF neurons, 228 neurons were recorded from the monkey HF during virtual navigation in a similar situation to a rodent water maze, in which distal cues were important to locate the animal's position. A subset of 72 neurons displayed place-related activity in one or more virtual spaces. Most place-related responses disappeared or changed their spatial tuning (i.e., remapping) when the arrangements of the distal cues were altered/moved in the virtual spaces. These specific features of the monkey HF might underlie neurophysiological bases of human episodic memory. |
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Keywords: | hippocampal formation place cell space cognitive map virtual reality |
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