口服鲨鱼肝再生因子脂质体对小鼠急性肝损伤的保护作用

为研究口服鲨鱼肝再生因子脂质体对四氯化碳(CCl4)和硫代乙酰胺(TAA)对小鼠急性肝损伤的保护作用,采用CCl4和TAA致小鼠肝损伤,观察肝组织切片,测定生化指标,检测小鼠给药后血清谷丙转氨酶(ALT)、血清谷草转氨酶(AST)活力。结果口服鲨鱼肝再生因子脂质体能明显减轻CCl4和TAA所致小鼠急性肝损伤模型的肝组织损伤作用,降低ALT、AST活力。因此口服鲨鱼肝再生因子脂质体对急性肝损伤也有明显的保护作用。

Protective Effect of Oral sHRF-lip Against Acute Hepatic Injury in Mice

Our objective is to investigate the protective effects of oral shark hepatic regenerative factor liposome(sHRF-lip) against acute hepatic injury in mice induced by CCl4 and TAA.Serum ALT and AST activities were analyzed.Taken orally sHRF-lip could remarkably reduce mouse blood serum ALT,and AST levels.The liver organization pathology inspection indicated that sHRF-lip has different abatement effect on the liver organizes destruction which was damaged by chemistry disruption.According to result analysis,sHRF-lip also has a protective function on the liver organizes destruction which was damaged by chemistry disruption.After it is absorbed in the alimentary tract,sHRF-lip protects the structure of liver cell membrane and subcellular organelle integrity,assuring the liver cell normal vital activity.These result may indicated that sHRF-lip could have the active function in the acute hepatitis treatment.