芬太尼与氯胺酮在小儿术后静脉镇痛中的对比研究

目的 对比研究芬太尼、氯胺酮在小儿术后静脉镇痛的安全性、有效性和适用性.方法 40例ASA Ⅰ～Ⅱ级小儿术后病人随机分为F(fentanyle),K(ketamine)两组,F组应用芬太尼,0.3μg·kg-1·h-1,K组应用氯胺酮80μg·kg-1·h-1,两组均采用PCA泵给予静脉自控镇痛,对比分析两组病人的镇痛效果、不良反应发生率.结果 两组在镇痛效果VAS,镇静程度比较无显著性差异,副作用K组高于F组.结论 芬太尼与氯胺酮在小儿术后自控静脉镇痛中安全性高、有效性好,氯胺酮不良反应发生率较芬太尼高.

Patient-controlled Analgesia in Children:a Comparison of Intravenous Fentanyle Versus Ketamine

Objective To compare the efficacy and safety of patient-controlled analge- sia in children by either intravenous fentanyle or ketamine.Methods Forty postopera- tive children with age from six months to twelve years were randomly allocated to patient-controlled intravenous fentanyle(F,n=20)group or ketamine (K,n=20)group.Write down the VAS,degree of tranquility ,incidence of side effect at time of 0hour,4hour, 8hour,12hour,24hour,48hour after operation.Results The postoperative VAS from 0hour to 48hour were low in the two groups.There were no significant difference between two groups.The incidence of side effect were significant higher in the K group than that in F group(P<0.05).Conclusion To intravenous fentanyle or ketamine in children postop- erative pain relief are good efficacy and high safety ways. The incidence of side effect were significant higher in the K group than that in F group.