葫芦岛市2012年健康人群脊髓灰质炎抗体水平监测分析

目的了解葫芦岛市健康人群脊髓灰质炎（简称脊灰）中和抗体水平,为及时制定免疫策略,维持无脊灰状态提供科学依据。方法随机调查葫芦岛市2个县区7个不同年龄组人群420名,采用细胞中和实验法检测脊灰中和抗体。结果被检测的420名人群脊髓灰质炎中和抗体阳性率为98.17%,其中Ⅰ型为99.05%、Ⅱ型为98.33%、Ⅲ型为97.14%,抗体几何平均滴度（gecmetric mean titer,GMT）值分别为1∶109.43、1∶69.16、1∶46.62。结论葫芦岛市健康人群脊髓灰质炎中和抗体阳性率较高,均〉95%,显示葫芦岛市健康人群有较高的脊灰免疫覆盖率。GMT也保持在较高水平,已形成抵御脊灰的免疫屏障。

Poliomyelitis antibody level monitoring analysis on health population of Huludao city in 2012

Objective To investigate the poliomyelitis （hereinafter referred to as polio） neutralizing antibody level among healthy population in Huludao city, to provide scientific basis for timely development of immuniza- tion strategy, to maintain polio free status. Methods A random survey of 2 counties , 7 different age groups of 420 people, with cell neutralization test method for the detection of poliovirus neutralizing antibodies. Results The positive rate was 98. 17% of polio neutralizing antibody among 420 cases been detected, the type I was 99.05% , type Ⅱ was 98.33% , type Ⅲ was 97.14% , antibody geometric mean titer （geometric mean titer, GMT） = 1 ： 109.43, 1 ： 69. 16 and 1 ： 46.62 respectively. Conclusions The polio positive rate of neutralizing antibody is higher in healthy population in Huludao city , all above 95 %, shows the healthy population in Hu- ludao had higher polio immunization coverage rate. GMT also maintained at a high level, has formed immuni- zation barrier to against polio.