Serum sCD14, polymorphism of CD14<sup><nobr>−260</nobr></sup> and periodontal infection期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Serum sCD14, polymorphism of CD14⁻²⁶⁰ and periodontal infection

Authors:	T Raunio M Knuuttila R Karttunen O Vainio T Tervonen

Institution:	Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland;;Specialist Dental Health Care Unit, City of Oulu, Oulu, Finland;;Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland;;Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki University Central Hospital, Laboratory Division (HUSLAB), Helsinki, Finland;;Department of Medical Microbiology, University of Oulu, Oulu, Finland;;Laboratory of Clinical Microbiology, Oulu University Hospital, Oulu, Finland

Abstract:	Background and Aims: CD14 is a co-receptor involved in the recognition of Gram-negative and positive bacteria. Infections are known to influence serum sCD14 levels, and CD14 gene promoter polymorphism (CD14 C?260T) has been reported to be associated with many infectious diseases. Our aim was to investigate whether serum sCD14 concentration is associated with periodontal infection and the CD14^?260 genotype. Subjects and Methods: The periodontal status of 56 subjects with chronic periodontitis and 28 controls was clinically examined. Serum sCD14 concentration was analyzed using ELISA and CD14^?260 genotype using polymerase chain reaction (PCR). Results: The mean concentration of sCD14 in serum was significantly higher in subjects with periodontitis than in control subjects (4.9 μ g ml^?1 vs 3.8 μ g ml^?1, P < 0.001). Serum sCD14 concentration associated significantly with the extent of advanced periodontal disease. In a regression analysis including both subject groups, the CD14^?260 genotype was a significant determinant for serum sCD14 concentration. After stratification by periodontal health status (periodontitis vs controls), the influence of the CD14^?260 genotype on serum sCD14 concentration was seen only in the control group. Conclusions: Periodontal infection is associated with the serum concentration of sCD14. Moderate to severe periodontal infection overshadows the influence of the genotype on serum sCD14 concentration.

Keywords:	periodontal disease sCD14 serum CD14 polymorphism

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