| 协同刺激分子B7-CD28/CTLA-4与自身免疫病 |
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| 引用本文： | 汤复根,吴俊英.协同刺激分子B7-CD28/CTLA-4与自身免疫病[J].国外医学：内科学分册,2007,34(4):232-234,242. |
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| 作者姓名： | 汤复根 吴俊英 |
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| 作者单位： | 蚌埠医学院免疫学教研室,安徽蚌埠233030 |
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| 摘 要： | T细胞需要两组信号刺激才能充分活化,一组由MHC抗原肽和TCR结合后提供;另一组由抗原递呈细胞提供的协同刺激信号.T细胞上的CD28/细胞毒性T淋巴细胞相关抗原4(Cytotoxic T lym-phocyte-associated antigen 4,CTLA-4(CD152)]与抗原递呈细胞上的B7(B7-1,B7-2)是目前发现的最为重要的协同刺激分子,它们在自身免疫病患者T细胞及抗原递呈细胞上有异常表达,且参与致病过程.
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| 关 键 词： | T细胞 协同刺激 B7-CD28/细胞毒性T淋巴细胞相关抗原4 自身免疫病 |
| 文章编号： | 1004-2369（2007）04-0232-03 |
| 修稿时间： | 2006-06-062007-01-09 |
Autoimmune disease associated with costimulatory molecules B7-CD28/CTLA-4 |
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| TANG Fu-gen,WU Jun-ying.Autoimmune disease associated with costimulatory molecules B7-CD28/CTLA-4[J].Foreign Medical Sciences(Section of Internal Medicine),2007,34(4):232-234,242. |
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| Authors: | TANG Fu-gen WU Jun-ying |
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| Institution: | Department of Immunology, Bengbu Medical College, Bengbu Anhui 233030, China |
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| Abstract: | T cells need two signals to promote their full activation. One is the combination of MHC antigen peptide and TCR, another is costimulatory signal from APC. CD28/CTLA-4 expressed on T cells and B7(B7-1,B7-2)on APC are the most important costimulatory molecules, which expressed abnormally on T cells and APC of patients with autoimmune diseases, indicates these costimulatory molecules are involved in the pathopoiesis of autoimmune diseases. |
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| Keywords: | T cells Costimulation B7-CD28/CTLA-4 Autoimmune disease |
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