| 先天性心脏病患者B19等病原感染的调查研究 |
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| 引用本文： | 王晓明,张国成,韩美玉,许东亮.先天性心脏病患者B19等病原感染的调查研究[J].中华微生物学和免疫学杂志,2000,20(2):170-172. |
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| 作者姓名： | 王晓明 张国成 韩美玉 许东亮 |
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| 作者单位： | 1. 第四军医大学西京医院老年病科
2. 第四军医大学西京医院儿科 |
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| 基金项目： | 国家计生委基金资助项目! (9736) |
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| 摘 要： | Objective To explore relationship of Parvovirus B19(B19), Toxoplasma
gondii(TOX), rubella virus(RV), cytomegalovirus (CMV) or herpes simplex virus type-2
(HSV-2) infection with congenital heart disease (CHD). Methods We conducted a
case-control study on detection of B19, TOX, RV, CMV or HSV-2 gene in cardiac tissue of 66
cases of CHD and 38 cases controls with polymerase chain reaction (PCR). Results 1) The positive rates of
B19, TOX, CMV and HSV-2 in 66 cases CHD were 18.2%, 15.2%, 25.8% and 4.5%, respectively,
while that in 38 cases control groups were 0%, 2.6%, 21.2% and 2.6%, reapectively. The
positively of B19, TOX was significantly different (P<0.05) between CHD and control
groups, while no statistical difference (P<0.05) for CMV and HSV-2. 2) Seven of 30
(23.3%) CHD were positive for RV-RNA, compared with control group which was all negative
(P=0.0327). Conclusion The results show that B19, TOX, RV infection mighet be
important risk factors for CHD, while CMV and HSV-2 had no relationship with CHD.
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| 关 键 词： | 先天性心脏病 微小病毒 弓形体 风疹病毒 |
| 修稿时间： | 1998-09-28 |
Study of Parvovirus B19 and other pathogenic infections in congenital heart disease |
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| WANG Xiaoming,ZHANG Guocheng,HAN Meiyu,et al..Study of Parvovirus B19 and other pathogenic infections in congenital heart disease[J].Chinese Journal of Microbiology and Immunology,2000,20(2):170-172. |
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| Authors: | WANG Xiaoming ZHANG Guocheng HAN Meiyu |
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| Institution: | WANG Xiaoming,ZHANG Guocheng,HAN Meiyu,et al. Department of Pediatrics,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,P.R.China Corresponding author:WANG Xiaoming,E mail:wangxiaoming16 @ hotmail.com |
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| Abstract: | Objective To explore relationship of Parvovirus B19(B19), Toxoplasma gondii(TOX), rubella virus(RV), cytomegalovirus (CMV) or herpes simplex virus type 2 (HSV 2) infection with congenital heart disease (CHD). Methods We conducted a case control study on detection of B19, TOX, RV, CMV or HSV 2 gene in cardiac tissue of 66 cases of CHD and 38 cases controls with polymerase chain reaction (PCR). Results 1) The positive rates of B19, TOX, CMV and HSV 2 in 66 cases CHD were 18.2%, 15.2%, 25.8% and 4.5% , respectively, while that in 38 cases control groups were 0%, 2.6%, 21.2% and 2.6%, reapectively. The positively of B19, TOX was significantly different ( P <0.05) between CHD and control groups, while no statistical difference ( P <0.05) for CMV and HSV 2. 2) Seven of 30 (23.3%) CHD were positive for RV RNA, compared with control group which was all negative ( P =0.0327). Conclusion The results show that B19, TOX, RV infection mighet be important risk factors for CHD, while CMV and HSV 2 had no relationship with CHD. |
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| Keywords: | Congenital heart disease Parrovirus B19 Toxoplasma Rubellavirus Cytomegalovirus Herpes simplex virus |
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