Role of dopamine D-1 and D-2 receptors in the ventral striatum in the turning behaviour of rats |
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| Authors: | N Koshikawa E Mori Y Maruyama N Yatsushige M Kobayashi |
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| Affiliation: | Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan. |
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| Abstract: | Systemically administered methamphetamine and apomorphine evoked characteristic turning when rats were pretreated with injections of D-1 and D-2 antagonists in the ventral but not in the dorsal striatum. The frequency of turning was greater for rats pretreated with D-2 antagonists (l-sulpiride and YM-09151-2) than for rats pretreated with a D-1 antagonist (SCH 23390). The responses were apparently additive when rats were pretreated with mixed D-1/D-2 antagonists, (cis(Z)-flupentixol and SCH 23390 + l-sulpiride). These results suggest that dopamine D-1 and D-2 receptors in the ventral striatum mediate turning behaviour through separate but cooperative mechanisms. |
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