The effect of ethanol on serum cyclosporine A levels in renal transplant recipients |
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| Authors: | M D Paul P S Parfrey M Smart H Gault |
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| Affiliation: | 1. Unité fonctionnelle de toxicologie, CHU de Lille, 59000 Lille, France;2. EA 4483, IMPact de l’environnement chimique sur la santé humaine (IMPECS), université de Lille, 59000 Lille, France;3. Laboratoire TOXGEN, 33100 Bordeaux, France;1. Regional centre of pharmacovigilance and pharmacoepidemiology, Reims university hospital, 51092 Reims, France;2. EA 3797 Vieillissement, Fragilité (VieFra), faculty of medicine, university of Reims Champagne-Ardenne, 51092 Reims, France;3. Department of clinical pharmacology and pharmacovigilance, regional pharmacovigilance centre of Marseille Provence Corse, Assistance publique–Hôpitaux de Marseille, 13005 Marseille, France;4. Department of medical pharmacology, Bordeaux university hospital, 33000 Bordeaux, France;5. Department of pharmacology, Rouen university hospital, 76000 Rouen, France;1. Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University, School of Medicine, Shanghai, China;2. Dermatology, Clinical Medical of Yangzhou University, Yangzhou, Jiangsu, China;3. Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;4. Department of Dermatology, Jinshan Hospital of Fudan University, Shanghai, China;5. Department of Dermatology, Minhang Hospital of Fudan University, Shanghai, China;6. Laser-Forschungslabor, LIFE Center, University Hospital of Munich, Munich, Germany;7. Department of Urology, University Hospital of Munich, Munich, Germany;1. Office of the Chief Medical Examiner, 7007-116 Street NW, Edmonton, Alberta, Canada;2. Principal Forensic Services, Bickley, Kent, UK |
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| Abstract: | Following an alcohol binge, cyclosporine A (CyA) levels rose by 100% in a 51-year-old transplant recipient treated with CyA. As CyA and ethanol are both metabolized by the cytochrome P-450 enzyme system, ethanol could theoretically interfere with CyA metabolism. Therefore, eight male renal transplant recipients were assessed in a crossover study to determine the effects of acute ethanol ingestion on CyA serum concentrations. CyA serum concentrations did not rise following 50 mL of 100% alcohol. We conclude that heavy alcohol intake may increase CyA levels but that acute moderate intake does not. |
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