Short term biomechanical effects of chymopapain injection; an in vitro investigation of human lumbar motion segments |
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| Affiliation: | 1. Orthopädische Universitätsklinik, Abteilung Biomechanik, Hüfferstrasse 27, D-4400 Münster FRG;2. Evangelisches Krankenhaus Bethesda, Orthopädische Klinik, Heerstrasse 219, D-4100 Duisburg FRG;1. Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom;2. Paediatric Spine Research Group, IHBI at Centre for Children''s Health Research, Queensland University of Technology, Brisbane, Australia;3. Centre for Applied Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, United Kingdom |
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| Abstract: | Intradiscal injections of therapeutic doses of chymopapain were performed on specimens of the human lumbar spine. The changes in disc height, intradiscal pressure and endplate stress distribution, as well as in bending and flexion mobility, were observed during 8 hours after the injection. Injection of isotonic saline was used for controls. The injection effects a temporary increase in disc height (and consequently a decrease in radial disc bulge) and a temporary increase of the intradiscal pressure. The stress distribution and motion segment mobility remain unchanged. No difference is noted between the chymopapain series and the saline controls. |
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