| 肝泰胶囊保护对乙酰氨基酚所致急性肝损伤实验研究 |
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| 引用本文： | 吴洋东,虞涤霞,刘红艳,高潇,程勇卫,段瑞娴,郭燕,唐望先. 肝泰胶囊保护对乙酰氨基酚所致急性肝损伤实验研究[J]. 中国药师, 2008, 11(6): 628-630 |
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| 作者姓名： | 吴洋东 虞涤霞 刘红艳 高潇 程勇卫 段瑞娴 郭燕 唐望先 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院肝病研究所,武汉,430030
2. 武汉市第七医院 |
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| 摘 要： | 目的探讨肝泰胶囊时对乙酰氨基酚(acetaminophen,AAP)所致小鼠急性化学性肝损伤的保护作用.方法随机将小鼠分为4组,每组10只.分别给予肝泰胶囊,联苯双酯(药物对照组),0.9%氯化钠溶液(空白对照组和模型组)干预10d后,采用AAP腹腔注射,造成急性实验性肝损伤.测定各组肝损伤后的血清谷氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST);肝组织中丙二醛(MDA)、谷胱甘肤(GSH)、过氧化物歧化酶(SOD);HE伊红染色观察病理改变,电镜下观察细胞器的变化.结果肝泰胶囊能明显降低AAP所致急性肝损伤小鼠的ALT、AST活性,同时提高肝组织中GSH、SOD水平,并能明显改善肝脏组织病理.结论肝泰胶囊对小鼠急性化学性肝损伤具一定的保护作用.
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| 关 键 词： | 肝泰胶囊 对乙酰氨基酚 肝损伤 小鼠 肝泰胶囊 保护 对乙酰氨基酚 急性肝损伤小鼠 实验 研究 Mice Acetaminophen Induced Acute Liver Injury Gantai Capsule 组织病理 肝脏 改善 水平 活性 结果 变化 细胞器 镜下观察 |
| 文章编号： | 1008-049X(2008)06-0628-03 |
| 修稿时间： | 2007-09-19 |
Protective Effect of Gantai Capsule on Acute Liver Injury Induced by Acetaminophen in Mice |
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| Wu Yangdong,Yu Dixi,Liu Hongyan,Gao Xiao,Cheng Yongwei,Duan Ruixian,Guo Yan,Tang Wangxian. Protective Effect of Gantai Capsule on Acute Liver Injury Induced by Acetaminophen in Mice[J]. China Pharmacist, 2008, 11(6): 628-630 |
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| Authors: | Wu Yangdong Yu Dixi Liu Hongyan Gao Xiao Cheng Yongwei Duan Ruixian Guo Yan Tang Wangxian |
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| Affiliation: | Wu Yangdong Liu Hongyan Gao Xiao Cheng Yongwei Duan Ruixian Guo Yan Tang Wangxian Institute of Liver Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030,China Yu Dixia Wuhan seventh hospital |
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| Abstract: | Objective:To investigate the protective effect of Gantai capsule on acute liver injury induced by acetaminophen in mice.Method:Forty mice were randomly divided into four groups:Gantai capsule,bifendate,0.9% natrii chloride and control group. Gantai capsule,bifendate and 0.9% natrii chloride were treated respectively.After 10 days,acute liver injury were induced by injec- ting acetaminophen into abdomen.The concentration of ALT,AST,GSH in serum and SOD,MDA in liver tissue were measured.The e- lectron microsc... |
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| Keywords: | Gantai capsule Acetaminophen Liver Injury Mice |
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