| 尼妥珠单抗联合DCF治疗晚期胃癌疗效观察 |
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| 引用本文： | 陈万灵,欧阳学农,王文武,余宗阳,钟连花,陈樟树,陈曦,张霞.尼妥珠单抗联合DCF治疗晚期胃癌疗效观察[J].癌症进展,2010,8(4):404-406. |
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| 作者姓名： | 陈万灵 欧阳学农 王文武 余宗阳 钟连花 陈樟树 陈曦 张霞 |
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| 作者单位： | 南京军区福州总医院肿瘤科,福州,350025;福建省肿瘤医院内科,福州,350025 |
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| 摘 要： | 目的观察尼妥珠单抗联合DCF方案治疗晚期胃癌的近期疗效及不良反应。方法30例晚期胃癌患者随机分成治疗组和对照组。治疗组采用尼妥珠单抗联合DCF方案治疗，对照组单用DCF方案治疗。结果30例患者均可进行评价。治疗组有效率（RR）为60．0％，疾病控制率（DCR）为80．0％；对照组RR为40．0％，DCR为53．3％。两组间RR、DCR比较均无统计学差异（P〉0．05）。治疗组与对照组主要的不良反应有疲乏、白细胞减少、恶心呕吐、脱发等，两组间比较无统计学差异（P〉0．05）。结论尼妥珠单抗联合DCF方案治疗晚期胃癌安全有效，值得进一步扩大样本研究。
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| 关 键 词： | 尼妥珠单抗 胃癌 多西他赛 顺铂 氟脲嘧啶 |
Clinical study on nimotuzumab combined with DCF regimen in the treatment of advanced gastric callcer |
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| Chen Wanling,Ouyang Xuenong,Wang Wenwu,Yu Zongyang,Zhong Lianhua,Chen Zhangshu,Chen Xi,Zhang Xia.Clinical study on nimotuzumab combined with DCF regimen in the treatment of advanced gastric callcer[J].Oncology Progress,2010,8(4):404-406. |
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| Authors: | Chen Wanling Ouyang Xuenong Wang Wenwu Yu Zongyang Zhong Lianhua Chen Zhangshu Chen Xi Zhang Xia |
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| Institution: | Chen Wanling~1 Ouyang Xuenong Wang Wenwu ~1 Yu Zongyang~1 Zhong Lianhua~2 Chen Zhangshu~1 Chen Xi~1 Zhang Xia~1 1 Department of Oncology,Fuzhou General Hospital,Nanjing Military Region,Fuzhou 350025,China 2 Department of Oncology,Cancer Hospital of Fujian Province,China |
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| Abstract: | Objective To evaluate the efficacy and toxicity of DCF regimen combined with nimotuzumab in treating advanced gastric carcinoma.Methods Thirty cases with advanced gastric cancer enrolled in this study were equally randomized into two groups:the research group(given nimotuzumab + DCF regimen) and the control group DCF regimen only.Results All thirty cases were evaluable for objective response.The response rate(RR) was 60.0%in the research group and 40.0%in the control group(P>0.05).There was also no signific... |
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| Keywords: | niraotuzumab gastric cancer docetaxel cisplatin fluorouracil |
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