T细胞受体二次重排的基础与临床

重组激活基因(RAG)能被诱导再次表达引起T细胞受体(TCR)二次重排,进而在TCR库的形成和丰富中发挥重要作用.二次重排发生于外周者称为受体修正(receptor revision),发生于中枢者则称为受体编辑(receptor editing).研究发现,TCR编辑/修正可存在于肿瘤、感染、移植及自身免疫等疾病状态下,且与疾病发生有密切联系.目前,国内外已有学者利用动物模型或人类细胞研究TCR编辑/修正,并对其机制进行了初步探索.

The experimental and clinical study on TCR secondary rearrangements

It is found that T cell receptor (TCR) may perform secondary rearrangement under the condition of indued recombination activating genes (RAG) re-expression, thus shaping and enriching the T cell repertoire. Peripheral and central changes of TCR are called receptor revision and receptor editing, respectively, and they may occur and play a role in neoplasm, infection, transplantation and autoimmune diseases. The naechanisms of TCR editing and revision are explored with both animal models and human cells. The progress in the research of TCR editing and revision is reviewed.