Genotoxic and oxidative responses in coelomocytes of Eisenia fetida and Hediste diversicolor exposed to lipid‐coated CdSe/ZnS quantum dots and CdCl2 |
| |
| Authors: | Gladys Saez Mélanie Aye Michel De Meo Ahissan Aimé Isabelle Bestel Philippe Barthélémy Carole Di Giorgio |
| |
| Affiliation: | 1. Laboratoire de Mutagenèse Environnementale, Institut Méditerranéen de Biodiversité et d'Ecologie, Faculté de Pharmacie, Aix‐Marseille Université, Marseille, Cedex 05, France;2. INSERM, U869, ARNA Laboratory, Bordeaux, France;3. University of Bordeaux, ARNA Laboratory, Bordeaux, France |
| |
| Abstract: | The emerging of Quantum Dots utilization in industrial or medicinal fields involved a potentially increase of these nanoparticles in environment. In this work, the genotoxic (comet assay) and oxidative effects (SOD activity, TBARS) of functionalized‐QDs and cadmium chloride were investigated on Hediste diversicolor and Eisenia fetida coelomocytes. Results demonstrated that functionalized‐QDs (QDNs) and cadmium chloride induced DNA damages through different mechanisms that depended on the nano‐ or ionic nature of Cd. The minimal genotoxic concentrations for H. diversicolor (<0.001ng/g for QDNs and CdCl2) were lower than for E. fetida (between 0.01 and 0.1 ng/g for QDNs, and between 0.001 and 0.01 ng/g for CdCl2). These results showed that H. diversicolor was more sensitive than E. fetida. The two contaminants had a low impact on the oxidative stress markers. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 918–926, 2015. |
| |
| Keywords: | cadmium genotoxicity invertebrates quantum dots |
|
|
