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Immunocorrecting properties of GB-115 dipeptide
Authors:E V Shipaeva  L P Kovalenko  S V Khaidukov  L G Kolik  T A Gudasheva  A D Durnev  S B Seredenin
Institution:(1) V. V. Zakusov Institute of Pharmacology, Moscow, Russia
Abstract:We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1–10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 548–551, May, 2008
Keywords:GB-115  phagocytosis  humoral and cellular immunity  immunophenotyping  cyclophosphamide
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