Screening for DJ-1 mutations in early onset autosomal recessive parkinsonism |
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Authors: | Ibáñez P,De Michele G,Bonifati V,Lohmann E,Thobois S,Pollak P,Agid Y,Heutink P,Dürr A,Brice A French Parkinson's Disease Genetics Study Group |
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Affiliation: | INSERM U289, Neurologie et Thérapeutique Expérimentale, H?pital de la Pitié-Salpêtrière, Paris, France. |
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Abstract: | The DJ-1 gene was identified as responsible for early onset autosomal recessive parkinsonism in two families (PARK7). In this study, after excluding mutations in the parkin gene, the authors screened a large series of early onset autosomal recessive parkinsonism families and consanguineous isolated patients of diverse geographic origins for DJ-1 mutations. No mutations were found. This indicates that PARK7 is not a common locus for early onset autosomal recessive parkinsonism, and that one or more new loci remains to be identified. |
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