Current concepts in the pathogenesis of nonalcoholic fatty liver disease. |
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Authors: | Nahum Méndez-Sánchez Marco Arrese Daniel Zamora-Valdés Misael Uribe |
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Affiliation: | Department of Biomedical Research, Gastroenterology & Liver Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico. nmendez@medicasur.org.mx |
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Abstract: | Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver disease, representing the leading cause of hepatology referral in some centres. However, its pathophysiology is not completely understood. Insulin resistance is one of the major mechanisms involved in disease prevalence and progression. Owing to the lack of an effective pharmacological therapy, recommendations on treatment are scarce and are based mainly on lifestyle changes, including diet and exercise. A review of the current literature on pathogenesis of NAFLD is presented in this article. |
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Keywords: | chronic liver disease insulin resistance metabolic syndrome nonalcoholic fatty liver disease nonalcoholic steatohepatitis |
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