| 敦煌石室大宝胶囊对衰老大鼠脑组织单胺类神经递质的影响 |
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| 引用本文： | 程容,段永强,成映霞,梁玉杰,王道坤.敦煌石室大宝胶囊对衰老大鼠脑组织单胺类神经递质的影响[J].中国老年学杂志,2010,30(4). |
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| 作者姓名： | 程容 段永强 成映霞 梁玉杰 王道坤 |
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| 作者单位： | 甘肃中医学院基础课部,甘肃,兰州,730000 |
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| 基金项目： | 甘肃省科技攻关计划项目，兰州市科技局计划项目 |
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| 摘 要： | 目的 观察敦煌石室大宝胶囊(DHDB)对衰老模型大鼠脑组织单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA) 和5-羟色胺(5-HT)含量的影响.方法 采用D-半乳糖建立大鼠衰老模型,测定大脑皮层内的NE、DA和5-HT含量.结果 模型组大鼠脑组织内NE、DA、5-HT含量与空白组比较均有明显降低(P<0.05),应用DHDB治疗后,治疗组大鼠脑组织内NE、DA、5-HT含量均显著增高(P<0.05).结论 DHDB可提高衰老模型动物脑组织单胺类神经递质的含量,对改善大脑功能有一定的作用.
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| 关 键 词： | 单胺类神经递质 衰老模型 大鼠 敦煌石室大宝胶囊 |
Effect of Dunhuang Shishi Dabao capsule on monoamine neurotransmitter in brain tissue of aging model rats |
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| CHENG Rong,DUAN Yong-Qiang,CHENG Ying-Xia,et al..Effect of Dunhuang Shishi Dabao capsule on monoamine neurotransmitter in brain tissue of aging model rats[J].Chinese Journal of Gerontology,2010,30(4). |
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| Authors: | CHENG Rong DUAN Yong-Qiang CHENG Ying-Xia |
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| Institution: | CHENG Rong,DUAN Yong-Qiang,CHENG Ying-Xia,et al. Department of Basic Subject,Gansu College of Traditional Chinese Medicine,Lanzhou 730020,Gansu,China |
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| Abstract: | Objective To explore the effect of Dunhuangdabao (DHDB) on monoamine neurotransmitter norepinephrine (NE) ,dopamine (DA) and 5-hydroxytryptamine (5-HT) levels in the brain tissue of aging model rats. Methods The subacutely aging model rats were made by injecting D-gal into abdominal cavity continually,and cerebral cortex NE,DA,and 5-HT levels were evaluated. Results The NE,DA and 5-HT levels in model group were significantly downregulated compared with those in normal group (P<0.05,P<0.05,P<0.05). After tre... |
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| Keywords: | Monoamine neurotransmitter Aging model Rats Dunhuang Shishi Dabao Capsule (DHDB) |
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