| 川芎嗪对吗啡依赖大鼠戒断综合征的抑制作用 |
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| 引用本文： | 胡祁生,汤剑清,魏劲波,杨青,杨芳,董峰,郭毅. 川芎嗪对吗啡依赖大鼠戒断综合征的抑制作用[J]. 中国药物依赖性杂志, 1999, 8(4): 270-271 |
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| 作者姓名： | 胡祁生 汤剑清 魏劲波 杨青 杨芳 董峰 郭毅 |
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| 作者单位： | 湖北医科大学生理教研室,武汉,430071 |
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| 摘 要： | 目的··:观察川芎嗪对吗啡依赖大鼠戒断综合征的影响。方法··:采用剂量递增方式皮下注射吗啡5d的大鼠,经过川芎嗪处理30min后,用纳洛酮催促,在停用吗啡后不同时间里观察评定戒断症状分值。结果··:川芎嗪明显减轻戒断症状和体重下降。结论··:川芎嗪能明显抑制吗啡依赖大鼠的戒断反应,其作用机制可能与阻断细胞钙内流有关。
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| 关 键 词： | 川芎嗪 吗啡 戒断综合征 大鼠 |
EFFECT OF LIGUSTRAZINE ON THE WITHDRAWAL SYNDROMES IN MORPHINE DEPENDENT RATS PRECIPITATED BY NALOXONE |
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| Hu Qisheng,Tang Jianqing,Wei Jingbo,Yang Qing,Yang Fang,Dong Feng,Guo Yi. EFFECT OF LIGUSTRAZINE ON THE WITHDRAWAL SYNDROMES IN MORPHINE DEPENDENT RATS PRECIPITATED BY NALOXONE[J]. Chinese Journal of Drug Dependence, 1999, 8(4): 270-271 |
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| Authors: | Hu Qisheng Tang Jianqing Wei Jingbo Yang Qing Yang Fang Dong Feng Guo Yi |
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| Abstract: | Objective: To study the effect of ligustrazine on the withdrawal syndromes of morphine dependent rat. Method: To establish a morphine dependent rat model by administration of gradually increased doses of morphine (from 20 mg·kg-1 to 100 mg·kg-1,5 days,sc);to precipitate withdrawal syndromes and evaluate the scores by naloxone(4 mg·kg-1,ip).Result: Ligustrazine could significantly reduce the withdrawal syndromes and weight lost. Conclusion: Ligustrazine is effective in inhibiting withdrawal syndromes of morphine dependent rats which may be related to its inhibition of calcium inward current. |
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| Keywords: | ligustrazine morphine withdrawal syndrome rat |
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