| 左旋多巴甲酯可增加斜视性弱视模型猫视皮质17区神经生长因子的表达 |
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| 引用本文： | 李勇文,林兴,黄仁彬,蒋伟哲,黎荣,张士军. 左旋多巴甲酯可增加斜视性弱视模型猫视皮质17区神经生长因子的表达[J]. 中国神经再生研究, 2011, 6(26) |
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| 作者姓名： | 李勇文 林兴 黄仁彬 蒋伟哲 黎荣 张士军 |
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| 作者单位： | 桂林医学院药理学教研室,广西医科大学药理学教研室,广西医科大学药理学教研室,广西医科大学药理学教研室,广西医科大学药理学教研室,广西医科大学药理学教研室 |
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| 基金项目： | the National Natural Science Foundation of China, No. 30760285*; the Education Innovation Plan Program for Postgraduate in Guangxi Zhuang Autonomous Region, No. 2008105981007D27* |
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| 摘 要： | 实验以处于发育敏感期的猫建立斜视性弱视动物模型，比较左旋多巴甲酯及左旋多巴对斜视性弱视猫视皮质17区神经生长因子表达的影响。图形视觉诱发电位结果和免疫组织化学检测结果显示，左旋多巴及左旋多巴甲酯均能缩短斜视性弱视模型猫P100波潜时，增大P100波幅，还能使其视皮质各层的内源性神经生长因子免疫阳性细胞数量增加，但左旋多巴甲酯的治疗效果优于左旋多巴。
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| 关 键 词： | 左旋多巴甲酯；斜视性弱视；神经生长因子；视皮质；猫；神经再生 |
Levodopa methyl ester increases nerve growth factor expression in visual cortex area 17 in a feline model of strabismic amblyopia |
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| Yongwen Li,Xing Lin,Shijun Zhang,Rong Li,Weizhe Jiang,Renbin Huang. Levodopa methyl ester increases nerve growth factor expression in visual cortex area 17 in a feline model of strabismic amblyopia[J]. Neural Regeneration Research, 2011, 6(26) |
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| Authors: | Yongwen Li Xing Lin Shijun Zhang Rong Li Weizhe Jiang Renbin Huang |
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| Affiliation: | Department of Pharmacology, Guilin Medical College, Guilin,,,,, |
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| Abstract: | In the present study, a feline model of strabismic amblyopia was established during a sensitive developmental period, and the influence of levodopa methyl ester and levodopa on nerve growth factor expression in the visual cortex (area 17) was compared. Pattern visual-evoked potential and immunohistochemistry results showed that levodopa methyl ester and levodopa treatment shortened P100 wave latency, increased P100 amplitude, and increased the number of endogenous nerve growth factor-positive cells in visual cortex levels. In particular, the effects of levodopa methyl ester were superior to levodopa treatment. |
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| Keywords: | levodopa methyl ester nerve growth factor strabismic amblyopia visual cortex neural regeneration |
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