肌萎缩侧索硬化患者可发生四肢体感诱发电位的变化

观察52例肌萎缩侧索硬化患者和30例健康人正中神经和胫后神经体感诱发电位变化，判断肌萎缩侧索硬化患者深感觉传导通路的功能状况。肌萎缩侧索硬化患者中，54%（28/52）出现体感诱发电位异常，且皆有下肢体感诱发电位异常。与健康对照者比较，近场皮质电位N20、P2、N2及中枢传导时间延长，可伴有波幅降低或者波形完全消失。表明54%肌萎缩侧索硬化患者体感诱发电位中四肢的中枢起源电位均发生明显异常，证实肌萎缩侧索硬化患者可伴有深感觉通路尤其是中枢深感觉传导障碍。

Changes in somatosensory evoked potentials elicited by stimulation of upper-limb and lower-limb nerves in amyotrophic lateral sclerosis patients

This study observed the changes in somatosensory evoked potentials between patients with amyotrophic lateral sclerosis (ALS) and healthy controls to evaluate the function of the central deep somatosensory pathway. In patients with ALS, 28 patients (54%) showed an abnormality in somatosensory evoked potentials. All had abnormal lower limb somatosensory evoked potentials. Compared with healthy controls, the abnormality in somatosensory evoked potential was characterized by prolonged N20, P2, N2 latency and central conduction time, with or without a decrease in wave amplitude or disappearance of waveform. Results showed marked alterations in the somatosensory evoked potential in cortical components of the upper and lower limb in 54% of patients with ALS, and confirmed that patients with ALS may also have a defective deep somatosensory pathway, particularly an abnormal central deep somatosensory pathway.