| 脊髓损伤大鼠损伤早期电位变化与损伤程度的关系 |
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| 引用本文： | 潘素颖,张广浩,霍小林,白金柱,宋涛. 脊髓损伤大鼠损伤早期电位变化与损伤程度的关系[J]. 中国神经再生研究, 2011, 6(23): 1780-1785 |
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| 作者姓名： | 潘素颖 张广浩 霍小林 白金柱 宋涛 |
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| 作者单位： | 中国科学院研究生院，中国科学院电工研究所,中国科学院研究生院，中国科学院电工研究所,中国科学院电工研究所,中国康复研究中心北京博爱医院脊柱脊髓外科,中国科学院电工研究所 |
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| 基金项目： | 中国科学院科技助残计划项目(KGLX2-YW-613)；北京市科技新星计划(2007B070) |
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| 摘 要： | To investigate characteristics of injury potentials after different degrees of spinal cord injury in rats,the present study established models of spinal cord contusion with severe,moderate,and mild degrees of injury.Injury potential was measured in vivo using a direct current voltage amplification system.Results revealed that in the first 4 hours after acute spinal cord injury,initial amplitude of injury potential was greatest after severe injury,followed by moderate and mild injuries.Amplitude of injury potential decreased gradually with injury time,and the recession curve was logarithmic.Under the same degree of injuries,amplitude of rostral injury potential was generally less than caudal injury potential.Results suggested that injury potential reflected injury severity,because large initial amplitude of injury potential during the early injury stage implied severe injury.
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| 关 键 词： | injury potential degree of injury spinal cord injury neural regeneration |
Injury potentials associated with severity of acute spinal cord injury in an experimental rat model |
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| pan suying,zhang guanghao,huo xiaolin,bai jinzhu and song tao. Injury potentials associated with severity of acute spinal cord injury in an experimental rat model[J]. Neural Regeneration Research, 2011, 6(23): 1780-1785 |
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| Authors: | pan suying zhang guanghao huo xiaolin bai jinzhu song tao |
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| Affiliation: | Graduate University of Chinese Academy of Sciences,,,, |
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| Abstract: | To investigate characteristics of injury potentials after different degrees of spinal cord injury in rats, the present study established models of spinal cord contusion with severe, moderate, and mild degrees of injury. Injury potential was measured in vivo using a direct current voltage amplification system. Results revealed that in the first 4 hours after acute spinal cord injury, initial amplitude of injury potential was greatest after severe injury, followed by moderate and mild injuries. Amplitude of injury potential decreased gradually with injury time, and the recession curve was logarithmic. Under the same degree of injuries, amplitude of rostral injury potential was generally less than caudal injury potential. Results suggested that injury potential reflected injury severity, because large initial amplitude of injury potential during the early injury stage implied severe injury. |
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| Keywords: | injury potential degree of injury spinal cord injury neural regeneration |
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