慢性鼻窦炎伴或不伴鼻息肉患者血清嗜酸粒细胞阳离子蛋白水平的比较

目的 比较慢性鼻窦炎伴有鼻息肉（CRSwNP）和不伴鼻息肉（CRSsNP）患者中血清嗜酸粒细胞阳离子蛋白（ECP）水平的差异。方法 采用ImmunoCAP100E系统，检测99例CRSwNP患者和59例CRSsNP患者的血清ECP水平，并与健康对照组84例比较。结果 三组间血清ECP水平的差异有统计学意义（P＜0.05），其中CRSwNP组明显高于健康对照组（P＜0.01），尤其是中-重度患者与健康对照组比较血清ECP水平显著升高（P＜0.01）。但CRSwNP组与CRSsNP组比较，差异无统计学意义（P＞0.05）；两组轻度与中-重度患者之间分别进行比较，差异均无统计学意义（P＞0.05）。结论 嗜酸粒细胞性炎症反应在慢性鼻窦炎伴或不伴鼻息肉的发病中可能均发挥了作用，但疾病的严重程度与炎性指标ECP的血清浓度之间未见明显相关性，有待进一步探讨。

Comparison of serum ECP levels between chronic rhinosinusitis patients with and without nasal polyps

Objective To compare the serum levels of eosinophil cationic protein (ECP) between chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). Methods Serum levels of ECP were investigated by using the ImmunoCAP100E system in patients with CRSwNP (n=99) and CRSsNP (n=59), and in healthy controls (n=84). Results Significantly different serum levels of ECP were observed among the CRSwNP, CRSsNP, and control groups (P＜0.05). Inter group analysis showed that the serum levels of ECP were significantly higher in patients with CRSwNP than in the controls (P＜0.01), especially in the moderate to severe group compared with the control group (P＜0.01). There was no significant difference between the CRSwNP and CRSsNP groups (P＞0.05), as well as between the mild and moderate to severe patients in the CRSwNP and CRSsNP groups(P＞0.05). Conclusion Eosinophilic inflammation may play a role in the pathogenesis of CRSwNP and CRSsNP, however, there is no relationship between disease severity and ECP levels in the serum.