Cell Death Induced by Baicalein in Human Hepatocellular Carcinoma Cell Lines |
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Authors: | Yuko Matsuzaki Norie Kurokawa Shuji Terai Yasuhiro Matsumura Nobuyuki Kobayashi Kiwamu Okita |
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Affiliation: | First Department of Internal Medicine, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yatnaguchi 755;Department of Virology and Parasitology, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yatnaguchi 755 |
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Abstract: | We examined the action of baicalein, a flavonoid contained in the herbal medicine sho-saiko-to (TJ-9), on three cell lines of human hepatocellular carcinoma (HCC). Treatment with baicalein strongly inhibited the activity of topoisomerase II and suppressed the proliferation of all three HCC cell lines. But the mode of cell death induced by baicalein differed according to the cell line. Baicalein induced apoptosis in a concentration-dependent mannner in only one cell line, and an increased concentration of baicalein produced cell death via necrosis in the other two lines. These results suggest that the inhibition of topoisomerase II is not by itself sufficient for induction of apoptosis, and that there is a more important mechanism which can account for the difference in susceptibility of cells to apoptosis induced by baicalein. |
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Keywords: | Baicalein Apoptosis Hepatocellular carcinoma Sho-saiko-to (TJ-9) Cell death |
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