Lymphomatoid papulosis: ultrastructural, immunohistochemical and gene analytical studies |
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Authors: | N MATSUYOSHI Y HORIGUCHI T TANAKA K TAKAHASHI N DOSAKA M FUJITA Y MIYACHI S IMAMURA |
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Institution: | Department of Dermatology, Faculty of Medicine, Kyoto University, Japan. |
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Abstract: | Ultrastructural, immunohistochemical and gene analytical studies were carried out on a 39-year-old patient with lymphomatoid papulosis. Two different cell groups were demonstrated in the papulonodular eruptions: large atypical cells with multiple nuclei that were well stained with anti-Tac, but not with Leu 3a, and other cells that possessed prominent hyperchromatic nuclei and which stained well with Leu I and Leu 3a but not with anti-Tac. Gene analytical studies using EcoRI, BamHI and HindIII revealed no rearrangement, indicating a non-clonal T-cell proliferation unlike malignant T-cell lymphoma. These results suggest that the present case was benign. |
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