Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results |
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Authors: | M S Kies B C Pecaro L I Gordon W W Hauck M J Kraut Y Krespi R H Ossoff C Schiff R Shetty G A Sisson |
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Affiliation: | 1. Boston, Massachusetts, USA;2. Brockton, Massachusetts, USA;3. Dover, New Hampshire, USA |
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Abstract: | We treated 19 consecutive patients with cisplatin, bleomycin, and methotrexate before definitive surgery or radiation therapy. Fourteen patients (74 percent) had partial or complete tumor regression after chemotherapy. With a minimum follow-up time of 27 months, none of the 4 patients who had a major histologic response relapsed, and only 2 of the remaining 15 patients continued disease-free. The achievement of a complete histologic response after preoperative chemotherapy may correlate with long-term disease-free survival after surgery and radiation therapy for head and neck cancer. |
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Keywords: | Requests for reprints should be addressed to James A. Gregg MD 110 Francis Street Boston Massachusetts 02215. |
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