Levels of antibodies against C1q and 60 kDa family of heat shock proteins in the sera of patients with various autoimmune diseases |
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| Authors: | Horváth L Czirják L Fekete B Jakab L Prohászka Z Cervenak L Romics L Singh M Daha M R Füst G |
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| Institution: | 2. Department of Animal Science, Texas A&M AgriLife Extension, College Station 77843;1. Department of Physical Therapy, Grand Valley State University, Grand Rapids, MI, United States;2. Spectrum Health, Department of Rehabilitation, Grand Rapids, MI, United States;3. Spectrum Health Offices of Research & Education, United States;4. Spectrum Health, Frederik Meijer Heart and Vascular Institute, Grand Rapids, MI, United States;1. Department of Critical Care Medicine, Qilu Hospital, Shandong University, 250012, Jinan, Shandong, China;2. Department of Orthopedics, Liaocheng People’s Hospital affiliated to Taishan Medical College, 252000, Liaocheng, Shandong, China;3. Department of Geriatrics, Qilu Hospital, Shandong University, 250012, Jinan, Shandong Province, China |
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| Abstract: | Previously a strong positive correlation was found between antibodies to C1q (C1qAb) and antibodies against human heat shock protein (hsp60) and mycobacterial hsp65 in HIV infected patients. Here the levels of these antibodies were measured in the sera of patients with different autoimmune diseases (122 systemic lupus erythematosus (SLE), 55 systemic sclerosis, 33 undifferentiated connective tissue disease (UCTD), 27 primary Raynaud syndrome, 21 rheumatoid arthritis (RA), 14 polymyositis/dermatomyositis (PM/DM), and 192 healthy blood donors. The prevalence of IgG C1qAb was found to be high (P<0.0001 as compared to the healthy controls) only in the SLE group. The levels of the anti-hsp60 (P=0.0094) and anti-hsp65 (P=0.0108) antibodies were high only in the UCTD patients. No correlation was found between the C1qAb and anti-hsp antibodies in any group except a significant (P=0.011) positive correlation between C1qAb and hsp65 antibodies in the patients with UCTD. These findings indicate that the autoantibodies against C1q are heterogeneous: in different diseases different types of C1qAb may dominate. |
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