新生儿Rh溶血病患儿IgG抗G的检测及意义

新生儿Rh溶血病(Rh HDN)是由于孕母体内的IgG类Rh系统抗体经胎盘进入胎儿体内与红细胞结合而引起的免疫性溶血性贫血。引起本病的Rh系统抗体主要有抗D、抗E、抗C、抗c等,以及有抗-Ce、抗-cE等复合抗体参与引起的新生儿溶血病的也时有报道〔1,2〕。然而,有抗G抗体(即抗CD抗体)参与引起的溶血病却少见报道。为此,我们对11例Rh溶血病患儿进行检测分析,现将结果报告如下。1材料与方法1.1标本来源2001年1月~2005年9月本院经新生儿Rh溶血病血型血清学检查确诊为Rh溶血病患儿11例,男5例,女6例,年龄1~7天。1.2试剂与仪器抗D、抗C、抗c、抗…

Detection and significance of IgG anti-G in patients with Rh hemolytic disease of newborn

Objective:To investigate detection and significance of IgG anti-G in serum and erythrocyte irradiation fluid of patients with Rh hemolytic disease of newborn.Methods:It was sensitized with O ccDee (Ccdee) standard erythrocyte that the serum and the irradiation fluid contained anti-D or/and anti-C identified with spectra cello. The sensitized erythrocyte was irradiated by indirect coomb test was used to identify IgG anti-G of the irradiation fluid with O Ccdee (ccDee).Results:There were anti-G in 3 patients' serum or/and irradiation fluid and gravidas' serum of 11 patients with Rh hemolytic disease and gravidas'o. And gravidas' Rh blood group were all ccdee.Conclusion:Anti-G can occur in newborn when gravida's Rh blood group is ccdee. It must be paid attention to that anti-G could intensify patients haemolysis in clinic blood transfusion.