Pathological features of gastric cancer in Zhuanghe high-risk area in China during 1992–2005 |
| |
Authors: | Yue-hua Gong Li-ping Sun Yan-hou Liu he Huang Guo-peng Sun Quan-gang Wang Yuan-jun Yin Yuan Yuan |
| |
Institution: | (1) Cancer Institute, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China;(2) Zhuanghe Center Hospital, Shenyang, Liaoning Province, 116400, China |
| |
Abstract: | Objective To investigate the pathological features and chronological changes of 1003 cases with gastric cancer in Zhuanghe high-risk
area during 1992–2005 and the relationship between the changes and etiology factors in order to make a clue for gastric cancer
prevention.
Methods A total of 1003 gastric cancer specimens resected surgically between 1992–2005 in Zhuanghe Center Hospital were studied. The
specimens were fixed in formalin and diagnosed by routine pathology.
Results The incidence of patients with gastric cancer was highest at age of 60–69, the next high was at age of 50–59 and it was significantly
higher in male than in female (P<0.001), the ratio was 3.0:1. During the past 14 years, there were 159 (15.9%) EGC, 195 (19.4%) moderate and 649 (64.7%) advanced
gastric cancer detected. In macroscopical features, type III remained dominant in EGC, the next was mixed type in EGC. In
advanced gastric cancer the Borrmann’s type III remained the dominant, the next was type II. For nodal metastasis, positive
cases were decreasing and negative were increasing in EGC, moreover negative cases were higher than positive ones each year.
There was no obvious trend in advanced cancer but positive cases were higher than negative ones each year. In histological
features, papillary, moderately and poorly differentiated tubular adenocarcinoma remained downtrend, mucus adenocarcinoma
and undifferentiation cancer remained uptrend year after year. The radio of intestinal to diffuse type decreased from 0.78
to 0.62 during the past 14 years.
Conclusion There were significant chorological trends of pathological characteristic of gastric cancer in Zhuanghe high-risk area during
the past 14 years.
This work was supported by the National “Tenth-Five” Key Technologies R&D Program of China (2004BA703B04-02) |
| |
Keywords: | Gastric cancer Pathological features Chorological changes |
本文献已被 SpringerLink 等数据库收录! |
|