Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese |
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| Authors: | Asahi Hishida Keitaro Matsuo Yasuyuki Goto Mariko Naito Kenji Wakai Kazuo Tajima and Nobuyuki Hamajima |
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| Institution: | (1) Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan;(2) Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan |
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| Abstract: | Background Previous studies have revealed the significance of Helicobacter pylori (H. pylori) infection as a risk factor of gastric cancer. Cytotoxin-associated gene A (cagA) positivity has been demonstrated to determine the clinical outcome of H. pylori infection in the presence of SHP-2 (src homology 2 domain-containing protein tyrosine phosphatase-2). This study aimed to
examine the formerly reported association of G/A PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) with gastric atrophy, as well as the association with gastric cancer in a Japanese population using
a large sample size. |
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