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Serum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia |
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| Authors: | K. Kojima M. Yasukawa T. Miyakuni A. Harashima Y. Matsuo T. Yano T. Sezaki H. Kobayashi M. Hara |
| Affiliation: | (1) Division of Hematology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, Japan e-mail: k-koji@sa2.so-net.ne.jp, Tel.: 0081-89-947-1111; Fax: 0081-89-943-4136, JP;(2) rtment of Medicine, Ehime University School of Medicine, Japan, JP;(3) Department of Medicine, Okinawa Prefectural Naha Hospital, Japan, JP;(4) Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Japan, JP;(5) Division of Hematology, National Okayama Hospital, Japan, JP;(6) Department of Medicine, Obihiro Kousei Hospital, Japan, JP |
| Abstract: | T-cell prolymphocytic leukemia (T-PLL) is a rare post-thymic T-cell neoplasm which shares most clinical features with adult T-cell leukemia (ATL). We measured serum level of C-terminal parathyroid hormone-related protein (C-PTHrP) in patients with T-PLL and ATL. Serum C-PTHrP levels of eight patients with T-PLL (median 36.8 pmol/l; range 27.0–50.2 pmol/l) did not differ from those of 30 human T-lymphotropic virus type I (HTLV-I)-seronegative blood donors (median 37.0 pmol/l; range 22.6–54.0 pmol/l). The C-PTHrP levels in ten ATL patients (median 69.6 pmol/l; range 42.5–899.4 pmol/l) were significantly higher than those in healthy controls (p<0.0001) or T-PLL patients (p=0.001). We suggest that the serum level of PTHrP can provide useful information for differentiating between T-PLL and ATL. Received: February 18, 1999 / Accepted: April 30, 1999 |
| Keywords: | T-cell prolymphocytic leukemia Adult T-cell leukemia Parathyroid hormone-related protein Human T-lymphotropic virus type I |
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