| 急性白血病患者P—糖蛋白和CD34的表达及其临床意义 |
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| 引用本文： | 林秀梅,祝平安.急性白血病患者P—糖蛋白和CD34的表达及其临床意义[J].湖南医科大学学报,2000,25(2):171-172. |
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| 作者姓名： | 林秀梅 祝平安 |
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| 摘 要： | 用免疫细胞化学ＡＢＣ法检测３０例急性白血病患者骨髓单个细胞Ｐ－糖蛋白（Ｐ－１７０）和ＣＤ３４的表达。结果示：Ｐ－１７０或ＣＤ３４表达在急性非淋巴细胞白血病组和急性淋巴细胞白血病组之间的差异不明显（Ｐ〉０．０５）；Ｐ－１７０或ＣＤ３４阳性表达组临床疗效差。与阴性表达组相比差异明显（Ｐ〈０．０５）。提示，同时检测两 中提高对急性白血病的疗效判断。
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| 关 键 词： | 急性白血病 P－糖蛋白 CD34 基因表达 |
Clinical significance of P-glycoprotein and CD34 expression of acute leukemia] |
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| X M Lin,Z X Xie,P A Zhu.Clinical significance of P-glycoprotein and CD34 expression of acute leukemia][J].Bulletin of Hunan Medical University,2000,25(2):171-172. |
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| Authors: | X M Lin Z X Xie P A Zhu |
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| Institution: | Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008. |
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| Abstract: | The expression of P-glycoprotein(P-170) and CD34 was detected in the bone marrow mononuclear cells of 30 patients with acute leukemia by immunocytochemical technique using JSB-1 and Tük 3 monoclonal antibody. The results were that expression of P-170 and CD34 had no significant difference between acute nonlymphoblastic leukemia and acute lymphoblastic leukemia(P > 0.05). The clinical therapeutic effect was poor in P-170 or CD34 positive patients and had significant difference compared with those negative patients(P < 0.05). Judgments of therapeutic effect for acute leukemia can be improved by detecting the expression of P-170 and CD34 simultaneously. |
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