| 钒酸盐纠正了糖尿病大鼠心肌组织内活化的DAG—PKC信息传导 |
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| 引用本文： | 梁自文,罗南渝.钒酸盐纠正了糖尿病大鼠心肌组织内活化的DAG—PKC信息传导[J].中华糖尿病杂志,1999,7(4):211-213. |
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| 作者姓名： | 梁自文 罗南渝 |
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| 作者单位： | 重庆市第三军医大学西南医院内分泌科!邮政编码，400038，重庆市第三军医大学西南医院内分泌科!邮政编码，400038，重庆市第三军医大学西南医院内分泌科!邮政编码，400038，重庆市第三军医大学西南医院内分泌科!邮政编码，400038 |
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| 摘 要： | 目的 探讨糖尿病大鼠心肌细胞内传导与心功能降低的关系。方法 检测糖尿病大鼠心肌二酰基甘油含量，蛋白激酶活性和心功能变化及胃饲钒酸钠的影响。结果 糖尿病大鼠心肌ＤＡＧ含量和胞膜ＰＫＣ活性显著升高，心功能显著降低，胃饲ＳＶ后明显改善。结论ＤＡＧ－ＰＫＣ通路激活是形成糖尿病心肌病的一个重要发病机制。
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| 关 键 词： | 糖尿病性 心肌病 蛋白激酶C 钒酸盐 |
The effect of vanadate on intracellular signal transduction of activated diacylglycerol-protein kinase C in myocardium of diabetic rats |
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| Liang Ziwen, Zhang Zhonghui, Luo Nanyu,et al.The effect of vanadate on intracellular signal transduction of activated diacylglycerol-protein kinase C in myocardium of diabetic rats[J].Chinese Journal of Diabetes,1999,7(4):211-213. |
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| Authors: | Liang Ziwen Zhang Zhonghui Luo Nanyu |
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| Abstract: | Objective To observe the intracellular signal transduction of DAG-PKC in relation to heart function.Methods Rat myocardial diacylglycerol (DAG) content, protein kinase C (PKC) activity were determined with change of heart function and stomach feeding of vanadate. Results The diabetic rats exhibited lower myocardial function,higher total intracellular diacylglycerd (DAG) levels and protein kinase C (PKC) activity. The treatment with vanadate resulted in a significant decrease in the elevated membranous PKC activity and total DAG levels in parallel with a significant increase in myocardial function. Conclusion These findings suggested that the activation of the DAG-PKC signal transduction induced by hyperglycemia in the heart cells was one of essential reasons causing diabetic cardiomyopathy. |
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| Keywords: | Diabetic cardiomyopathy Protein kinase C Vanadate |
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