| 马桑内酯致痫后大鼠海马生长抑素mRNA表达的变化 |
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| 引用本文： | 周厚纶,朱长庚.马桑内酯致痫后大鼠海马生长抑素mRNA表达的变化[J].解剖学报,1997,28(2):123-126. |
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| 作者姓名： | 周厚纶 朱长庚 |
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| 作者单位： | 同济医科大学解剖学教研室 |
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| 摘 要： | 为探讨马桑内酯致痫与生长抑素的关系，用原位杂交组织化学法研究了马桑内酯致痫后大鼠海马生长抑素ｍＲＮＡ阳性神经元的变化，结果表明：致痫组大鼠ＣＡ１，ＣＡ２区及齿状回生长抑素ｍＲＮＡ的反应明显增强，以上各区的中，小神经内生长抑素ｍＲＮＡ神经元的数目及强度明显高于正常对照组，两者有显著性差异。
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| 关 键 词： | 生长抑素 mRNA 海马 癫痫 原位杂交 马桑内酯 |
CHANGES OF SOMATOSTATIN mRNA EXPRESSION IN HIPPOCAMPUS FOLLOWING CORIARIA LACTONE INDUCED KINDLING IN RATS |
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| Abstract: | In order to probe into relationship between seizure induced by coriaria lactone(CL)with somatostatin(SOM),changes in SOM mRNA containing hippocampal neurons were investigated by using in situ hybridization histochemistry following CL induced kindling in rats.The result showed that the number and intensity of SOM mRNA containing both small and middle size neurons in CA 1,CA 2 area and dentate gyrus in the experimental group were higher prominently than that in the control group with significant difference.It indicates that SOM containing hippocampal neurons may participate in pathological process of epileptic state following CL induced kindling. |
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| Keywords: | SOM mRNA containing neurons Hippocampus Epilepsy In situ hybridization histochemistry Rat |
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