A STUDY OF THE EFFECTS OF DEXCLAMOL AS THE NEUROLEPTIC COMPONENT IN NEUROLEPTANAESTHESIA

In a double-blind cross-over study in dogs, dexclamol was comparedwith droperidol as the neuro-leptic component of a neuroleptanalgesiccombination. Fentanyl was the narcotic analgesic. Neuro-leptanaesthesiawas induced with a mixture of the neuroleptic, the analgesicand nitrous oxide in oxygen. Dexclamol 200 ng/kg i.v. was aseffective as droperidol at the same dose in inducing neuro-lepsyand in supplementing nitrous oxide anaesthesia. Changes in heartrate, respiratory rate and rectal temperature in the animalstreated with dexclamol were not different from those observedin the animals treated with droperidol. A comparison of theadrenolytic properties of dexclamol and droperidol was madeon the isolated rabbit aortic strip. Both compounds produceda parallel shift to the right of the noradrenaline cumulativedose-response curves, indicating competitive antagonism. ThepA2 values showed dexclamol to be approximately 15 times lesspotent than droperidol in inhibiting the noradrenaline-inducedcontraction of the rabbit aortic strip