枳实消痞丸联合复方阿嗪米特治疗功能性消化不良的临床研究

目的探讨枳实消痞丸联合复方阿嗪米特治疗功能性消化不良的临床疗效。方法选取2016年5月—2017年5月在济宁市第一人民医院就诊的功能性消化不良患者110例,依据用药的差别分为对照组(55例)和治疗组(55例)。对照组口服复方阿嗪米特肠溶片,150 mg/次,3次/d。治疗组在对照组基础上口服枳实消痞丸,6 g/次,3次/d。两组均连续治疗4周。观察两组患者临床疗效,比较治疗前后两组患者临床症状评分、健康问卷(PHQ-15)、尼平消化不良指数(NDI)、焦虑自评量表(SAS)和抑郁自评量表(SDS)评分及血清学指标。结果治疗后,对照组和治疗组总有效率分别为81.82%、96.36%,两组比较差异有统计学意义(P0.05)。治疗后,两组餐后饱胀、食欲不振、反酸、上腹胀痛等症状评分均显著降低(P0.05);且治疗组各临床症状评分显著低于对照组(P0.05)。治疗后,两组PHQ-15、NDI、SAS和SDS评分均明显降低(P0.05);且治疗组这些评分明显低于对照组(P0.05)。治疗后,两组血清神经肽S受体-1(NPSR1)、降钙素基因相关肽(CGRP)、胃动素(MTL)、P物质(SP)水平均明显升高(P0.05);且治疗组比对照组升高更明显(P0.05)。结论枳实消痞丸联合复方阿嗪米特治疗功能性消化不良可有效改善患者临床症状和生活质量,具有一定的临床推广应用价值。

Clinical study of Zhishi Xiaopi Pills combined with Compound Azintamide in treatment of functional dyspepsia

Objective To investigate the clinical efficacy of Zhishi Xiaopi Pills combined with Compound Azintamide in treatment of functional dyspepsia. Methods Patients (110 cases) with functional dyspepsia in Jining No.1 People''s Hospital from May 2016 to May 2017 were divided into control (55 cases) and treatment (55 cases) groups according to different treatments. Patients in the control group were po administered with Compound Azintamide Enteric-coated Tablets, 150 mg/time, three times daily. Patients in the treatment group were po administered with Zhishi Xiaopi Pills on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, PHQ-15, NDI, SAS, and SDS scores, and serum markers in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.82% and 96.36%, respectively, and there were differences between two groups (P < 0.05). After treatment, the postprandial fullness, anorexia, acid reflux, distention and pain of the upper abdomen scores in two groups were significantly decreased (P < 0.05). And these clinical symptom scores in the treatment group were more obviously lower than those in the control group (P < 0.05). After treatment, the PHQ-15, NDI, SAS, and SDS scores in two groups were significantly decreased (P < 0.05). And these scores in the treatment group were more significantly lower than those in the control group (P < 0.05). After treatment, the serum NPSR1, CGRP, MTL and SP levels in two groups were significantly increased (P < 0.05). And the serum markers levels in the treatment group were more significantly higher than those in the control group (P < 0.05). Conclusion Zhishi Xiaopi Pills combined with Compound Azintamide can effectively improve the clinical symptoms and quality of life in treatment of functional dyspepsia, which has a certain clinical application value.