| 鹿芪方对高血压合并心力衰竭大鼠血压、血管紧张素-醛固酮和心肌胶原纤维的影响 |
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| 引用本文： | 刘茜,周华,瞿惠燕,戎靖枫,封舟,王咏.鹿芪方对高血压合并心力衰竭大鼠血压、血管紧张素-醛固酮和心肌胶原纤维的影响[J].天津中医药,2018,35(1):36-40. |
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| 作者姓名： | 刘茜 周华 瞿惠燕 戎靖枫 封舟 王咏 |
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| 作者单位： | 上海中医药大学附属曙光医院心内科、心血管研究所, 上海 201203,上海中医药大学附属曙光医院心内科、心血管研究所, 上海 201203,上海中医药大学附属曙光医院心内科、心血管研究所, 上海 201203,上海中医药大学附属曙光医院心内科、心血管研究所, 上海 201203,上海中医药大学附属曙光医院心内科、心血管研究所, 上海 201203,上海中医药大学附属曙光医院心内科、心血管研究所, 上海 201203 |
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| 基金项目： | 国家自然科学基金面上项目（81373625）；国家自然科学基金面上项目（81673753）。 |
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| 摘 要： | 目的]研究鹿芪方对高血压合并心力衰竭大鼠血压、血管紧张素Ⅰ(AngⅠ)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)和心肌胶原纤维的影响。方法]采用腹主动脉缩窄术致高血压合并心力衰竭大鼠模型,造模成功后,将大鼠随机分为模型组,对照组,假手术组,鹿芪方高、中、低剂量组。给药8周后测量大鼠血压。应用双抗体夹心酶联免疫吸附法测定大鼠AngⅠ、AngⅡ、ALD水平。采用苦味酸天狼星红染色观察大鼠心肌胶原纤维改变。结果]与模型组相比,鹿芪方各剂量组能有效降低心力衰竭大鼠的收缩压(P0.05),其中高、中剂量组优于低剂量组(P0.05)。与模型组比较,鹿芪方各剂量组能有效降低AngⅠ、AngⅡ及ALD(P0.05),在降低ALD方面,鹿芪方高剂量组明显优于低剂量组(P0.01)。通过对大鼠心肌天狼星红染色发现,鹿芪方各剂量组较模型组而言,能显著减少心肌胶原纤维含量,改善心肌间质形态,鹿芪方高剂量组要优于鹿芪方中、低剂量组。结论]鹿芪方能降低心力衰竭大鼠的血压,调节神经内分泌的激活,减轻心肌纤维化,改善心室重构从而减轻心肌受损。
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| 关 键 词： | 鹿芪方 高血压 心室重构 心力衰竭大鼠 |
| 收稿时间： | 2017/9/26 0:00:00 |
Effect of Luqi formula on blood pressure, angiotensin-aldosterone and myocardial collagen fibers in rats with hypertension complicated with heart failure |
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| LIU Qian,ZHOU Hu,QU Huiyan,RONG Jingfeng,FENG Zhou and WANG Yong.Effect of Luqi formula on blood pressure, angiotensin-aldosterone and myocardial collagen fibers in rats with hypertension complicated with heart failure[J].Tianjin Journal of Traditional Chin Medicine,2018,35(1):36-40. |
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| Authors: | LIU Qian ZHOU Hu QU Huiyan RONG Jingfeng FENG Zhou and WANG Yong |
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| Institution: | Cardiovascular Department and Cardiovascular Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Cardiovascular Department and Cardiovascular Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Cardiovascular Department and Cardiovascular Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Cardiovascular Department and Cardiovascular Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,Cardiovascular Department and Cardiovascular Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and Cardiovascular Department and Cardiovascular Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | |
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| Keywords: | Luqi formula hypertension ventricular remodeling heart failure rat |
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